Jay P McLaughlin Selected Research

Trans-Activators (Trans-Acting Factor)

12/2022	SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice.
1/2021	In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain.
6/2014	Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat.
6/2013	Conditional Tat protein expression in the GT-tg bigenic mouse brain induces gray matter density reductions.

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Jay P McLaughlin Research Topics

Disease

18	Pain (Aches) 11/2023 - 06/2009
11	Respiratory Insufficiency (Respiratory Failure) 08/2023 - 06/2009
9	Hyperalgesia 11/2023 - 05/2004
8	Neuralgia (Stump Neuralgia) 06/2022 - 05/2004
7	Chronic Pain 06/2022 - 01/2019
6	Cocaine-Related Disorders (Cocaine Addiction) 12/2022 - 07/2002
6	Substance-Related Disorders (Drug Abuse) 09/2022 - 06/2009
6	HIV Infections (HIV Infection) 09/2022 - 01/2014
6	Neurocognitive Disorders (Clerambault Syndrome) 01/2021 - 01/2015
4	Constipation 01/2021 - 04/2013
3	Inflammation (Inflammations) 08/2023 - 01/2021
3	Infections 01/2021 - 06/2013
2	congenital stationary Night blindness 08/2023 - 09/2022
2	Cognitive Dysfunction 12/2022 - 06/2012
2	Memory Disorders (Memory Loss) 01/2022 - 04/2012
2	Dementia (Dementias) 10/2021 - 01/2015
2	Alcoholism (Alcohol Abuse) 01/2021 - 06/2012
2	Opioid-Related Disorders (Opiate Addiction) 11/2020 - 01/2020
2	Neuroinflammatory Diseases 09/2015 - 01/2015
1	Sleep Wake Disorders 09/2022
1	Pruritus (Itching) 01/2022
1	Virus Diseases (Viral Diseases) 01/2022
1	Mood Disorders (Mood Disorder) 01/2022
1	Substance Withdrawal Syndrome (Withdrawal Symptoms) 11/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021
1	Binge Drinking 01/2021
1	Disease Progression 01/2021

Drug/Important Bio-Agent (IBA)

11	Opioid Analgesics (Opioids)IBA 11/2023 - 05/2004
10	Analgesics (Analgesic Drugs)IBA 11/2023 - 06/2015
10	Morphine (MS Contin)FDA LinkGeneric 11/2023 - 06/2009
9	Cocaine (Cocaine HCl)IBA 08/2023 - 09/2014
6	LigandsIBA 11/2023 - 06/2012
6	tat Gene Products (tat Protein)IBA 01/2022 - 01/2014
5	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 08/2023 - 09/2014
4	Trans-Activators (Trans-Acting Factor)IBA 12/2022 - 06/2013
4	Opioid Receptors (Opioid Receptor)IBA 08/2022 - 05/2004
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2014
3	sigma-2 receptorIBA 06/2022 - 01/2019
3	Formaldehyde (Formol)FDA Link 01/2021 - 01/2019
2	Mitochondrial DNA (mtDNA)IBA 08/2023 - 01/2021
2	Dopamine (Intropin)FDA LinkGeneric 12/2022 - 01/2020
2	Biomarkers (Surrogate Marker)IBA 09/2022 - 10/2021
2	sigma Receptors (sigma Receptor)IBA 06/2022 - 01/2019
2	Gabapentin (Neurontin)FDA LinkGeneric 06/2022 - 01/2019
2	Human Immunodeficiency Virus tat Gene ProductsIBA 01/2022 - 04/2012
2	kappa Opioid Receptors (kappa Opioid Receptor)IBA 01/2022 - 06/2012
2	CJ 15,208IBA 01/2022 - 01/2020
2	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 01/2019
2	TeaIBA 07/2021 - 11/2020
2	Dynorphins (Dynorphin)IBA 06/2012 - 05/2004
1	Naloxone (Narcan)FDA LinkGeneric 11/2023
1	Peptides (Polypeptides)IBA 11/2023
1	Serum Amyloid A Protein (Serum Amyloid A)IBA 08/2023
1	Hydrocortisone (Cortisol)FDA LinkGeneric 08/2023
1	Complement C3 (C3 Complement)IBA 08/2023
1	C-Reactive ProteinIBA 08/2023
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 08/2023
1	phenylalanyl- cyclo(cysteinyltyrosyl- tryptophyl- ornithyl- threonyl- penicillamine)threoninamide (CTOP)IBA 02/2023
1	Adenosine (Adenocard)FDA LinkGeneric 09/2022
1	purineIBA 09/2022
1	pyrimidineIBA 09/2022
1	Inosine FDA Link 09/2022
1	Uridine Monophosphate (UMP)IBA 09/2022
1	NucleotidesIBA 09/2022
1	Long Noncoding RNAIBA 09/2022
1	Messenger RNA (mRNA)IBA 09/2022
1	MicroRNAs (MicroRNA)IBA 09/2022
1	Sigma-1 ReceptorIBA 01/2022
1	Amino Acids FDA Link 01/2022
1	dimethyl sulfone (methylsulfonylmethane)IBA 01/2022
1	Dimethyl FumarateIBA 01/2022
1	AntioxidantsIBA 01/2022
1	ChromatinIBA 01/2022
1	Doxycycline (Periostat)FDA LinkGeneric 01/2022
1	Histones (Histone)IBA 01/2022
1	Indomethacin (Indometacin)FDA LinkGeneric 01/2022
1	Lysine (L-Lysine)FDA Link 01/2022
1	Sucrose (Saccharose)IBA 01/2022
1	Tyrosine (L-Tyrosine)FDA Link 01/2022
1	Opioid Peptides (Opioid Peptide)IBA 01/2022
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2022
1	N-Terminal AcetyltransferasesIBA 01/2022
1	mitragynineIBA 07/2021
1	mitragynine pseudoindoxylIBA 07/2021
1	AlkaloidsIBA 07/2021
1	Glutathione (Reduced Glutathione)IBA 01/2021
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2021
1	corynoxineIBA 01/2021
1	ArrestinIBA 01/2021
1	Taurine FDA Link 01/2021
1	Ethanol (Ethyl Alcohol)IBA 01/2021
1	BMS-986122IBA 01/2021
1	1-benzylpiperazineIBA 01/2021
1	hirsutineIBA 01/2021
1	Therapeutic UsesIBA 11/2020
1	VincamineIBA 01/2020

Therapy/Procedure

13	Therapeutics 08/2022 - 07/2002
2	Analgesia 01/2021 - 01/2021
1	Intravenous Administration 08/2022
1	Injections 01/2022